Variation in guide RNA library representation results in gene effect score bias in genome-wide CRISPR screens.

BMC Genomics · 2026 · PMC13023172 · PMID 41715004

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highly significantno p-value reported

For both Humagne C and D libraries, the correlations were highly significant, indicating that Chronos does not (effectively) adjust for the variability associated with pDNA representation.

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