Distribution of Sequencing Coverage Gaps in Exomes and Genomes: Potential Implications for Diagnostic Accuracy in Neurodevelopmental Disorder Genes.

Samples tended to cluster according to batch of origin, indicating systematic rather than random variation with highly significant differences in LCR-associated z-scores across batches (Kruskal–Wallis p < 2.2 × 10 −16 ) and multiple significant pairwise contrasts identified by Wilcoxon tests.

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