Hypertension and Diabetes Cooperatively Drive HSP90 Activation, HSP70 Suppression, and Left Ventricular Interstitial Expansion: Relevance to Maladaptive Myocardial Remodeling.

Strikingly, the comorbid AH+DM condition induced an extreme and highly significant elevation of HSP90 mRNA expression, suggesting a synergistic stress response at the transcriptional level ( Figure 6 ).

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