Temporal Trends in and Associations With Nonsteroidal Anti-inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease.

As supported by the multivariable model, the advent of more effective immunosuppressive medications over time (eg, bDMARDs and tsDMARDs) is another factor likely contributing to the decreasing rate of prescription NSAID use due to better control of underlying IBD and associated musculoskeletal disease, but there is still a decreasing trend in NSAID prescription independent of immunosuppressive regimen.

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