Hematopoietic progenitor kinase 1 inhibitor BGB-15025 induces apoptosis in acute myeloid leukemia cells through the cell cycle pathway and mitogen-activated protein kinase/extracellular signal-regulated kinase pathway signaling axis.

Anticancer Drugs · 2026 · PMC13034767 · PMID 41503684

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a decreasing trendno p-value reported

BGB-15025, identified as a targeted inhibitor of HPK1, has been validated in our preliminary results; notably, the expression levels of HPK1 exhibited a decreasing trend with increasing drug concentrations.

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