Genetic origins and proteomic consequences of kinetoplast loss in trypanosomes.

PLoS Pathog · 2026 · PMC13035230 · PMID 41880374

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highly significantno p-value reported

More proteins reported a highly significant (-log 10 False Discovery Rate [FDR] >4) reduction in abundance relative to proteins that reported increased abundance following kDNA loss (168 v 51), and a closer inspection of >2-fold depleted proteins revealed kDNA-binding proteins and mitochondrial RNA-processing factors ( Fig 6B ), consistent with destabilisation of these proteins after loss of all mitochondrial DNA and RNA.

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