Utility of cerebrospinal fluid circulating tumor cell quantification and next-generation sequencing in patients with suspicion for leptomeningeal disease.

Patient C showed an increasing trend in CTCs, which suggested a lack of treatment response; NGS allowed for the discovery of MET amplification and a resistance to EGFR TKI prompting a change in therapeutic strategy to a combination therapy of capmatinib and osimertinib.

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