The mechanisms by which hypothalamic neuroinflammation induced by neonatal cerebral ischemia-hypoxia leads to decreased thymic function via the HPA axis.

Cell Biosci · 2026 · PMC13036901 · PMID 41731625

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Hypothalamic CRH levels showed no significant chang on day 1 post-HI, exhibited an increasing trend on day 3, increased significantly on the day 7 ( P < 0.05), and then tended to decrease thereafter (Fig. 3 D).

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