3.6 NaB exacerbates the mitochondrial regulation of BSMCs by the NDUFS2 Co-treatment of NaB with NDUFS2 gene resulted in a highly significant increase in ATP levels ( P < 0.05; Figure 6A ) and ROS levels ( P < 0.01; Figure 6B ).
In a previous study conducted by our research group, we observed that the addition of 1 mm NaB and the induction of cell differentiation for 12 h resulted in the following phenomenon: the intracellular ROS level exhibited an increasing trend, while concurrently, the cellular ATP content and the number of mitochondria increased, although the MMP decreased ( 14 ).