NAT10-mediated ac4C RNA acetylation stabilizes CXCL5/DEK mRNA to drive proliferation and metastasis in lung adenocarcinoma.

Cell Death Dis · 2026 · PMC13039259 · PMID 41862454

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a decreasing trendno p-value reported

Upon NAT10 knockout in A549 cells, we observed a decreasing trend in the levels of CXCL5 and DEK mRNAs, and the half-life of both mRNA molecules continued to be significantly shortened (Fig. 4j ).

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