Lactate-mediated macrophage polarization promotes splenomegaly in acute erythroleukemia.

Interestingly, splenic lactate content showed no significant change during the early post-infection period (30–51 dpi) but exhibited an increasing trend in the late disease stage (approximately 58–68 dpi) (Fig. 1A , bottom), indicating that lactate accumulation in the spleen is not an early event in AEL.

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