PARK7-Nrf2 axis mitigates NLRP3-driven inflammation to rescue neurovascular unit from hypoxia/reoxygenation-induced necroptosis.

J Transl Med · 2026 · PMC13040751 · PMID 41742164

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an increasing trendno p-value reported

Western blot analysis revealed that with the prolonged reoxygenation time following OGD/R+QVD-induced cortical neuron injury in rats, the expression levels of PARK7 and Nrf2 proteins showed an increasing trend, peaking at 12 hours of reoxygenation (Fig. 4 A).

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