Activating mutations in ESR1 contribute to an immunosuppressive breast tumor microenvironment by dampening cytokine secretion.

MIC ESR1 Y541S tumors showed a decreasing trend in IFN-γ + immune cells, with no significant differences in Lag3 + , Tim3 + , or TNF-α + CD3 + T cells or in TNF-α + CD161 + NK cells between the genotypes ( Supplemental Figure 7, C, and F–I , and Supplemental Figure 8, A and B ).

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