However, LDH release increased according to genotype in the remaining 3 CAPS lines, and the linear-trend test was highly significant, supporting a strong genotype–phenotype relationship among the CAPS alleles.
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Mice humanized by syntenic replacement with full-length NLRP3 disease-associated variants model the clinical cryopyrinopathy continuum.
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However, this increase did not achieve significance, likely because of the variation in this parameter between mice ( Figure 1B ).