Multi-omic profiling converges on proteasome subunits PSMA7/PSMB2 as targets of the sepsis-protective agent Handelin.

Front Immunol · 2026 · PMC13043404 · PMID 41939900

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP < 0.001actually significant

Sensitivity analysis revealed that this result was strongly influenced by GSE185263 : after excluding this study, the association became highly significant (SMD ≈ -0.90, P < 0.001) with reduced heterogeneity, whereas removal of other studies yielded non-significant P-values.

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marginally significantno p-value reported

Transcriptomic meta-analysis across 10 independent cohorts revealed that PSMA7 expression was significantly higher in non-survivors than survivors, while PSMB2 showed a similar trend that was marginally significant and sensitive to cohort composition.

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