THP-1-derived polarized macrophages differ by drug transporter transcriptomics, P-glycoprotein activity and rifampicin uptake kinetics.

Arch Toxicol · 2026 · PMC13043547 · PMID 41511522

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

borderline significantP = 0.06so close (0.05 < p ≤ 0.1)

After 4 h, this difference remained borderline significant: While M1 macrophages accumulated 12.6 ± 3.7 ng rifampicin/ng protein, M2 cells only exhibited 9.2 ± 3.9 ng rifampicin/ng protein ( P = 0.06).

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