High amplitude bubble continuous positive airway pressure decreases lung injury in rats with ventilator-induced lung injury.

compared BCPAP and conventional CPAP for managing respiratory distress syndrome in preterm babies and reported a significant reduction in postnatal steroid use when BCPAP was used and a decreasing trend for the incidence of chronic lung disease when BCPAP was used. 22 In an observational study from Canada, Pelligra et al. compared ventilator-derived CPAP and BCPAP according to an analysis of the treatment of 821 babies < 32-weeks-old and discovered that BCPAP use significantly reduced exogenous surfactant and postnatal steroid use and mechanical ventilation duration. 23 This lung protective effect of BCPAP is compatible with our previous work; 16 it may partially explain the reason that preterm babies receiving CPAP had a lower BPD incidence compared with mechanically ventilated babies.

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