TDP-43-driven alternative splicing of UQCRC2 modulates mitochondrial bioenergetics.

TDP-43 depletion impairs mitochondrial function via UQCRC2 mis-splicing during aging The critical nature of this TDP-43-UQCRC2 axis was further underscored by analysis of human expression data, which revealed a robust and highly significant positive correlation between the two genes across tissues (Fig. 6 A).

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