Protective Gene Signatures in the Transition from SIRS to Sepsis: Insights from Integrative Transcriptomics and Validation Across Clinical Cohorts.

Infect Drug Resist · 2026 · PMC13050167 · PMID 41939278

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

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boldest claim

The sentences

marginal significancep = 0.05actually significant

Specifically, CTSS showed a clear separation in survival outcomes between the higher- and lower-expression cohorts ( p = 0.0042), while NRG1 showed marginal significance ( p = 0.05).

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highly significantno p-value reported

Among all modules, MEgrey exhibited the strongest linkage to the SIRS condition, as reflected by its correlation value of 0.78 and a highly significant p -value of 1e−04.

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