Improved genotype inference reveals cis- and trans-driven variation in the loss-of-heterozygosity rates in yeast.

We find the same trend when we separate iLOH and tLOH events, although the bias among iLOH events after applying the revised method remains marginally significant ( P = 0.024; Supplementary Table 3 in Supplementary File 2 ).

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Homolog bias We find that 661 (51.3%) out of 1,288 detected LOH events converted toward the BY homolog, which is not significantly different from the binomial expectation ( P = 0.20), in contrast to a strong and highly significant 65.9% BY-bias among LOH events detected by the standard pipeline.

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