Stress factors can also significantly affect the expression and functional balance of Th17 cells: when mice are induced to produce stress responses through social failure, the number of Th17 cells in their spleen tissue significantly increases ( 75 ); The Th17/Tregs ratio in the liver and ileum tissues of mice under chronic stress showed an increasing trend ( 155 ).Th17 cells play a promoting role in the occurrence and development of depressive like behavior, and this conclusion has been fully validated through various experimental methods, including exogenous IL-17A stimulation ( 149 ); Using antibodies for IL-17A neutralization intervention ( 109 ,
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