HLA Class II Protein Expression Regulation Is Strongly Linked to Cis-Acting SNPs.

These correlations are highly significant, although not particularly strong ( R = 0.43–0.67), and suggest that CIITA may be regulating the HLA class II loci within a given individual in a somewhat uniform manner, which concurs with the highly conserved CIITA binding site (across both the HLA class II loci and across individuals).

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The top hit for HLA‐DP protein expression, rs3128928, associates with HBV in a similar manner as the previously described HBV‐associated SNP rs9277534 [ 7 ], though with only borderline significance.

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