highly significantp < 0.001
We verified this by testing the overlap between the TF motif-gene cis -regulations inferred by MLC as applied to the LiCAT-seq human embryonic development dataset, 38 and the cis -regulations inferred by MethCorTarget applied to the DNAme human embryonic development dataset 39 : we found a highly significant overlap, odds ratio OR = 13.3 ( 12.9 − 13.8 ) ( p < 0.001 , Fisher’s exact test).