Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer's disease neuropathology.

Beyond differences at these sites, we found highly significant genotype-associated differences in DNAm at sites and groups of sites annotated to many genes, including Dcaf5 (chr12:80436248, effect size = 0.39, FDR = 1.3E−12), Arsi ( n = 6 CpG sites, chr18:60917760 - chr18:60917679, mean effect size = −1.51, Empirical Brown’s method: P = 4.64E−6), Creb3l4 ( n = 2 CpG sites, chr3:90243866 - chr3:90243888, mean effect size = −2.34, Empirical Brown’s method: P = 5.03E−05), and As3mt ( n = 5 CpG sites, chr19:46730273 - chr19:46730349, mean effect size = 1.48, Empirical Brown’s method: P = 3.46E−4) (Fig. 2B , Supplementary Data S2 ).

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