Proteomic signatures of COVID-19 Post-Vaccination/Post-Infection Syndrome (PV/PIS): insights into immune dysregulation and coagulopathy.

Even the modestly significant fold changes, as observed in ITIH3 and ITIH4 in our study, could initiate a “snowball effect” facilitating amyloidogenic cross-seeding and disproportionate incorporation into insoluble heterogeneous amyloid deposits (microclots), thereby amplifying their pathological impact beyond what is suggested by fold change alone.

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