Neuronal and glial cell alterations involved in the retinal degeneration of the familial dysautonomia optic neuropathy.

To our surprise, at P7 – a time when neurogenesis and astrocyte migration to the retina is complete, and the reduction in the number of RGCs in the CKO is not yet significant – we observed robust anti‐GFAP staining along with an irregular or “crowded” and hypertrophic appearance of astrocytes in the CKO compared to the control (Figure 4a,b ).

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