7 A); ( ii ) the expression level of miR-12137-3p followed an increasing trend in HIV-infected patients on B/F/TAF regimen and three out of the five HIV-infected patients on D/C/F/TAF at 24weeks (Fig. 6 ); and ( iii ) it could potentially bind to 3’-UTR region of 5 putative mRNA targets that could modulate weight gain: MRAP2, PPARA, PPARγ-2, WNT1, and WNT3A (Fig. 7 C).
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A crucial role for novel miR-12137-3p in supporting weight gain in treatment naïve HIV-infected patients on antiretroviral therapies.
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