Association of circulating proteasome activity with Alzheimer's pathology and cognitive functions in APOE ε4 carriers.

Alzheimers Res Ther · 2026 · PMC13059596 · PMID 41761294

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highly significantno p-value reported

The interaction term for APOE ε4 status was highly significant for HV/ICV ( p for interaction < 0.001), indicating that the effect of proteasome activity on hippocampal atrophy differed markedly by genetic risk.

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