Combined single-cell transcriptome and Mendelian randomization to identify and validate prognostic genes associated with endoplasmic reticulum stress and butyrate metabolism in lung adenocarcinoma.

The results demonstrated that the risk score remained a highly significant independent predictor of OS after full adjustment for these clinical covariates [Hazard Ratio (HR) = (1.03), 95% Confidence Interval (CI): (1.023)–(1.036), P < 0.001] ( Figure 6B ; Supplementary Table S15 ).

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