Notably, highly significant interaction effects were found between Aβ 42/40 ratio change from pre to post intervention and the increase in SW amplitude during all three nights (E1 x Aβ 42/40 change: β = 166.1, p < 0.001; E2 x Aβ 42/40 change: β = 87.6, p < 0.001; E3 x Aβ 42/40 change: β = 150.6, p < 0.001, see Table 3 A, left panel).
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Deep sleep slow wave-spindle coupling is selectively linked to plasma amyloid-β levels in older adults in clinical trials.
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