Evaluation of immunoglobulin A1/immunoglobulin A2 ratio and B cell lymphoma-6 in relation to apoptosis-associated speck-like protein in diabetic kidney disease patients.

ASC also showed a highly significant adjusted difference between the groups after adjustment of duration of diabetes as a covariate (Wald χ2=29.810, p < 0.001*) (Table 4 ).

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In addition, it has been reported that innate-immune activation via toll-like receptor 9 (TLR9) may be significant in diabetic renal injuries through the overproduction of glycosylated IgA1, leading to enhanced immune-complex formation and glomerular deposition [ 41 ].

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