Unraveling the complexity of skin's biological aging utilizing epigenetic clocks.

Clin Epigenetics · 2026 · PMC13063880 · PMID 41957838

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a weak trendno p-value reported

This is supported by the observation of only a weak trend in methylation changes at these CpGs towards a younger methylome (Fig. 4 C) and aligns with previous findings that CpGs with a greater impact on healthy longevity do not necessarily undergo substantial methylation changes during aging [ 114 ].

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