Dichotomous SMAD2/3 regulation and selective antihypertrophic activity of heparin during in vitro chondrogenesis of mesenchymal stromal cells.

Of note, treatment with 10 μg/mL heparin slightly but significantly reduced the day-28 levels of MEF2C , IBSP, and ALPL mRNAs relative to control pellets (dashed line), while the reduction of COL10A1 , IHH , and GLI1 expression in all but one donor failed to reach significance (Fig. 5 A).

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