High serum ferritin is associated with genetic instability in myelodysplastic neoplasms.

The number of cytogenetic aberrations showed a trend towards significance across groups, with a median of 1 aberration (range 0–3) in group 1, 0 aberrations (range 0–5) in group 2, and 2 aberrations (0–3) in group 3 ( p = 0.044).

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When comparing patients with SF ≤ 275 μg/L to those with SF > 275 μg/L, the OR for the average number of γH2AX-foci in CD34+ PB cells was 9.87 (95% CI: 1.10–164.28, p = 0.063), and thus borderline significant after adjustment for bone marrow blast count.

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