A three-part model for the self-controlled case series design to estimate and characterize adverse event risk in an overlapping risk period after multiple vaccines: application to ischemic stroke following Pfizer-BioNTech bivalent COVID-19 vaccine and influenza vaccine.

9 Another SCCS study identified a marginally statistically significant elevated risk of ischemic stroke among individuals <65 years who received the Pfizer-BioNTech bivalent COVID-19 vaccine and the influenza vaccine on the same day. 10 Overlapping risk periods can also occur when 2 doses of the same vaccine are administered in close succession, such as in the 2-dose primary series of mRNA COVID-19 vaccines (Pfizer-BioNTech COVID-19 vaccine [BNT162b2] and Moderna COVID-19 vaccine [mRNA-1273]).

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