SOD1 lactylation impair its enzymatic activity by conformational change to aggravate intervertebral disc degeneration.

Nat Commun · 2026 · PMC13066621 · PMID 41764208

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an increasing trendno p-value reported

Homeostatic NPCs account for a dominant proportion in mild-degenerated NP tissues and decrease with the progression of IVDD, while two fibrotic NPCs showed an increasing trend from grade II to grade V in NP tissues (Fig. 1A , B).

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