Chronic activation of p38α in skeletal muscle causes necrotic changes, but also abolishes expression of MK2, MK3, and MKK6 and the muscle recovers.

J Biol Chem · 2026 · PMC13066812 · PMID 41791712

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not as significantno p-value reported

When p38α D176A+F327S is expressed in all mouse tissues, MK2 downregulation was significant, but the protein was still detectable ( 46 ); and when p38α D176A+F327S was expressed specifically in the liver there was an effect on MK2, but not as significant as in muscle ( 51 ).

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