highly significantP=0.006
Second, stratifying the cohort by the clinical eGFR cut-off of 60 mL/min/1.73 m 2 revealed a clear moderating effect: the GMV reduction in the CI group was not significant in patients with eGFR ≥60 mL/min/1.73 m 2 (P=0.148) but was highly significant in those with eGFR <60 mL/min/1.73 m 2 (P=0.006; Table S3 ).