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<i>GPR176</i> represses mitophagy to promote the progression of osteosarcoma by facilitating mTORC1 activity via PI3K-AKT pathway.

Transl Cancer Res · 2026 · PMC13066992 · PMID 41969458

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an increasing trendno p-value reported
In this study, immunofluorescence revealed that the LC3 protein, which co-localizes with mitochondria, showed an increasing trend after GPR176 knockdown, and the protein levels of mitophagy-related proteins were dysregulated after GPR176 downregulation.

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