Targeted delivery of lupeol via hyaluronic acid-modified ZIF-8 for anti-hepatic fibrosis therapy.

Mater Today Bio · 2026 · PMC13067125 · PMID 41970248

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highly significantno p-value reported

Notably, the HA/Lupeol@ZIF-8 group (G5) exhibited the most significant therapeutic effect: the expression of FXR (P < 0.001), SHP (P < 0.0001) and BSEP (P < 0.001) was restored to near-normal levels, showing highly significant differences compared to the model group.

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