highly significantP < 0.001
Statistical significance was defined as follows: P < 0.05, significant; P < 0.01, highly significant; P < 0.001, very highly significant; and P < 0.0001, extremely highly significant.
Statistical significance was defined as follows: P < 0.05, significant; P < 0.01, highly significant; P < 0.001, very highly significant; and P < 0.0001, extremely highly significant.