Induction of ROS-mediated genomic instability, mitochondrial deploarization and p53-independent mitochondrial apoptotic cell death by bioactive glass nanoparticles in human A431 epidermoid skin cancer cells.

This severe genotoxic effect was evidenced by highly significant increases ( p < 0.001) in key comet assay parameters: tail length, %DNA in the tail, and tail moment, when compared to untreated control cells, as shown in Table 2 and illustrated in Fig. 3 .

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