Gut Microbiota-Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol-Induced Cognitive and Social Dysfunction via CB1R-DRD2-RAP1 Signaling Axis.

To retrospectively validate this sample size, we note that the key behavioral outcomes (e.g., Novel object recognition, Barnes maze, and Three‐chamber social test) yielded extremely significant differences ( p < 0.001) with very large effect sizes (Cohen's d > 1.7), confirming the adequacy of our experimental design to detect robust effects.

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