Cardiovascular risk associated with polypharmacy in heart failure: a systematic review and meta-analysis.

ESC Heart Fail · 2026 · PMC13070473 · PMID 41711224

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hedged sentence

0.0001

closest p · 0.0× alpha

0.0001

boldest claim

The sentences

highly significantP < .0001actually significant

The trim-and-fill analysis imputed two additional studies, resulting in an adjusted pooled HR of 1.24 (95% CI: 1.13–1.37), which remained highly significant ( P < .0001) and similar to primary analysis.

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