Early versus late initiation of long-acting insulin in paediatric and adult diabetic ketoacidosis: A systematic review and meta-analysis of randomised control trials.

Diabetes Obes Metab · 2026 · PMC13071216 · PMID 41657118

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closest p · 1.8× alpha

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a nonsignificant trendp = 0.09so close (0.05 < p ≤ 0.1)

In subgroup analyses, adult studies 9 , 20 , 21 , 24 (four studies) showed a nonsignificant trend toward higher risk with long‐acting insulin (RR: 1.41, 95% CI: 0.95–2.10, p = 0.09; I 2 = 0%), whereas paediatric studies 11 , 22 , 25 (three studies) showed no difference (RR: 1.06, 95% CI: 0.68–1.66, p = 0.79; I 2 = 42%).

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