Adenosine Pathway Activation Defines Genetically Linked Immunosuppressive Subtypes in Solid Tumor Brain Metastases.

Notably, a numerical trend towards inferior outcomes was observed in highly immunogenic brain metastases characterized by combined adenosine pathway activation and high PD-L1 expression (adenosine high/PD-L1 high), which may indicate a clinically relevant high-risk phenotype and further underscore the unmet medical need for an expansion of immunotherapeutic strategies in brain metastases.

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