Autophagy-Mitophagy Pathway-Linked Genetic Variants Associate with Systemic Inflammation and Interact with Dietary Factors in Asian and European Cohorts.

Int J Mol Sci · 2026 · PMC13072760 · PMID 41977248

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0530

boldest claim

The sentences

highly significantp < 0.001actually significant

Notably, meat showed a highly significant interaction in continuous analysis ( p < 0.001) but not in categorical analysis ( p = 0.204), demonstrating that continuous measures can detect dose–response relationships that may be obscured by categorization.

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borderline significancep = 0.053so close (0.05 < p ≤ 0.1)

Among dietary and lifestyle variables, only flavonoid intake showed nominal interaction with GRS ( p = 0.037), while fat intake showed borderline significance ( p = 0.053); neither passed the Bonferroni correction.

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marginal significanceno p-value reported

Associations with CVD and allergy were weak or inconsistent, showing marginal significance in UKBB but not in KoGES.

also in 3,113 other papers

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