Source-Specific Photobiomodulation Regulates Mitochondrial Bioenergetics, Redox Signaling, and Functional Outputs in C2C12 Myoblasts Across Replicative Aging.

Int J Mol Sci · 2026 · PMC13073692 · PMID 41977188

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0940

boldest claim

The sentences

highly significantp < 0.0001actually significant

This analysis revealed highly significant main effects of dose (F 4,160 ≈ 848.5, p < 0.0001), wavelength (F 1,160 ≈ 252.2, p < 0.0001), and cellular age-status (F 1,160 ≈ 1466.8, p < 0.0001), indicating that metabolic activity varied significantly with PBM fluence, irradiation source, and replicative aging.

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a nonsignificant trendp = 0.094so close (0.05 < p ≤ 0.1)

NIR significantly enhanced fusion relative to both the control ( p = 0.014) and LED ( p = 0.047), while LED treatment alone showed only a nonsignificant trend toward improvement compared with the control ( p = 0.094).

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