Retrospective analysis of postoperative adjuvant therapy and survival in T4 esophageal squamous cell carcinoma: a dual-cohort study using SEER and Chinese multicenter data.

Front Med (Lausanne) · 2026 · PMC13076103 · PMID 41987784

Europe PMC DOI

hedged sentence

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

of borderline significancep = 0.058so close (0.05 < p ≤ 0.1)

In the node-positive subset ( n = 95) radiotherapy retained a protective effect: pre-operative radiotherapy remained significant (HR 0.22, 95% CI 0.08–0.60, p = 0.003), while postoperative radiotherapy was of borderline significance (HR 0.36, 95% CI 0.12–1.04, p = 0.058).

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