Schisantherin A promotes neural differentiation of stem cells from apical papilla to improve mandibular development via mental nerve repair.

the blank group at 1 week ( P < 0.05) (Western blot only showed an increasing trend), with no intergroup differences at 2 weeks; for nestin (Fig. 5 B–D2), both fluorescence and Western blot results increased significantly in the control and all experimental groups vs. the blank group at 1 week (the 10 − 9 mol/L group had the strongest fluorescence and a significant increase vs. the control) ( P < 0.05), while fluorescence remained higher vs. the blank group at 2 weeks but WB detected no intergroup differences; for SOX2 (Fig. 6 B, C), Western blot showed no expression in any group at 1 and 2 weeks.

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